منابع مشابه
Antiangiogenesis in haematological malignancies.
Angiogenesis, the growth of new capillary blood vessels, is a central regulator of cancer growth, and a validated target for cancer therapy. The antiangiogenic agents in clinical use target one or more cellular pathways involved in the cascade of vascular growth. In haematological malignancies, angiogenesis occurs within a bone marrow ecosystem comprised of closely apposed malignant cells, endo...
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Fever is the principle sign of infection in neutropenic patient and frequently may be the only evidence of infection. The pattern of fever in neutropenia is non-specific and not pathognomonic of any type of infections or non-infectious process and can be suppressed by the antipyretic effects of drugs such as corticosteroids. Neutropenia, resulting from cytotoxic chemotherapy is the most common ...
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Sixty nine patients with various types of haematological malignancies were studied. Chronic myeloid leukaemia (n =32) was the commonest diagnosis. The patients were assessed on Hamilton Rating Scale for Depression, PGI-N(2) Health Questionnaire and Presumptive Stressful Life Events Scale and those who had scores above the cut off points for Hamilton Rating Scale and/or PGI-N(2) Health Questionn...
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Increased knowledge of the immunophenotypic, cytogenetic and molecular heterogeneity of haematological diseases has challenged the traditional approach to disease classification based on morphology. In the current WHO classification, an integrated approach combining clinical details, morphology, immunophenotyping and genetic features is used for the diagnosis of haematological malignancies. An ...
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Tumour angiogenesis plays a key role in the pathogenesis and progression of haematological malignancies. Thereby, pro- and anti-angiogenic growth factors and cytokines regulate the angiogenic process. The most important growth factor, vascular endothelial growth factor (VEGF) and its signaling through its receptors 1 and 2, is not only involved in solid tumours, but there is also emerging evide...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1997
ISSN: 0021-9746
DOI: 10.1136/jcp.50.5.361